TopicsSupplements and minerals
Methylene blue
For mitochondrial support
Most of the experts we follow recommend it.
Methylene blue shows promise for mitochondria, but panel is split on regular use.
Who is behind it
Voices including a molecular biology PhD, a nutritional sciences PhD and a board-certified internal medicine doctor.
How strong the research is
Backed by some published research, and by what the experts see in practice.
In their words
“methlyene blue is used to raise blood pressure with 200 milligrams intravenously over one hour followed by an infusion of 0.25 to 2 milligrams per hour”
a nutritional sciences PhD
Oral doses differ significantly from intravenous doses, and starting low helps avoid excessive intake.
Doses should be titrated slowly with home measurements of glucose, ketones, and lactate to reduce lactate into the lower end of 0.5 to 1.5 millimoles per liter range.
Methylene blue supports energy production and detoxification simultaneously acting as a redux cycler and antioxidant
Methylene blue is a potent viral inhibitor and generally an all round Swiss Army knife of supplements.
With care
Some of the minds attach conditions. These are worth reading before you begin.
Methylene blue has demonstrated meaningful anti-tumour activity in research settings.
Methylene blue may help increase transthyretin and decrease misfolding of beta-amyloid, potentially mitigating pollutant effects.
Talk it through
Entrain shows what the experts teach, so you can make better decisions with your own clinician. It does not diagnose or prescribe. If something is worrying you, start there.
How this reading was made
Every line here comes from a doctor, scientist or coach speaking publicly, and links to the moment they said it. Entrain listens for where independent experts arrive at the same place on their own, and shows where they part ways. Backed by some published research, and by what the experts see in practice.
Some statements come from sponsored segments or people speaking about their own products. They are marked where they appear and count for less. Last refreshed 4 September 2026.
The research beneath it
- Protection against neurodegeneration with low-dose methylene blue and near-infrared light.Frontiers in cellular neuroscience, 2015
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